18+ Uchi no Mei Shimai ga Yuuwaku shitekuru.

Shiori and Mio's parents are away on a two-year business trip, so it's a good thing they've got their uncle around to watch the house! He's watching more than just the wallpaper, though. Sharing a home with two attractive girls means his eyes tend to wander, though of course he keeps his hands (and thoughts) to himself... that is, until Mio lets slip that her older sister Shiori is actually in love with her uncle! With the cat out of the bag, Shiori pushes her relationship with her uncle as far as it can go—and for his drop-dead gorgeous niece, he's willing to let her take things all the way! With all that fun happening under the one roof, it's not long until Mio decides she wants to join in too...

(Source: J18 Publishing)